Hiring Full Remote Employees Outside the US as a US-Based Company

Attention US-based recruiters! I’m curious to hear about the challenges associated with hiring candidates who wish to work remotely from outside the US. For instance, think about a German national living in Peru, collaborating with a US-based company while operating in the same time zone.

What specific hurdles might arise when hiring someone like this, as opposed to a candidate located in the US?

Thank you for your insights!